Resumen To thrive on this planet with a 24 h day:night cycle, we are designed to have almost every gene in our genome to rise and fall at an appropriate time in at least one organ. This dynamic pattern of gene expression and function sustains health and vitality. Now, we live in an anthropogenic world […]

Resumen Tumor development is driven by changes to the genome leading to fitness advantages underlying successive clonal expansions. As somatic changes occur across most or all cell cycles, the cancer genome carries an archeological record of its past. Over the past years, we have developed several approaches to mine that archeological record from the cancer […]