Jean C. Zenklusen. Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, US https://gdc.cancer.gov/about-gdc/gdc-team/jean-claude-zenklusen-phd Frontiers in Genomics

Summary: Since Eric Davidson's work on the organization of regulatory elements in enhancers, syntactic properties of the arrangements - order, distances, orientation - of regulatory sites have been evaluated. There are thus various “enhancer grammars”. In that context I show the difference with the grammatical model of microbial transcriptional regulation. On the other hand, the […]

Resumen de la plática At a big picture level, my group at CMU is focused on studying the adaptive properties of spatial structure, across different biological systems. Spatially-resolved datasets are revolutionizing knowledge across many areas in biology, yet are under-utilized for questions in evolutionary biology. When it comes to understanding the role that population structure […]

Summary: Human microbiomes are remarkably person specific. In the skin microbiome, individuals have similar species, yet each person has a unique consortia of strains. How these unique consortia form and persist remains a fundamental open question. To understand the assembly of these complex communities, the Lieberman Lab reconstructs the recent on-person evolution of strains on […]

Resumen de la plática Genomic studies are transforming precision medicine, yet their benefits often overlook diverse, underserved populations. Our research shows that embracing ancestral diversity not only addresses this ethical concern but also enhances genomic discovery, resolution, interpretation, and contextualization. Analyzing lung diseases across multiple biobanks, we found consistent genetic effects and improved our understanding […]

Resumen de la plática Proteins are the machines of life. These diverse macromolecules are essential for all cellular processes. Nature has generated an impressive set of proteins through evolution. Many of its structures and even more sequences are known by now. This enormous amount of data can be leveraged for protein design. The design of […]

Resumen de la plática El cáncer surge debido a la acumulación de alteraciones en el genoma de las células. Estas alteraciones pueden ir desde mutaciones puntuales hasta pérdida y ganancia de cromosomas completos. La caracterización de estas alteraciones en el genoma de las células neoplásicas a través de la aplicación de metodologías de análisis genómico […]

AVISO: por solicitud de la ponente, este seminario no se transmitirá por YouTube. Resumen de la plática Erythrocytes are specialized cells that carry haemoglobin throughout the bloodstream in all vertebrates. Obtention of mature erythrocytes involves genome-wide chromatin compaction, gain of heterochromatin, and gene silencing, making the erythroid genome a unique scenario to investigate chromatin architecture […]

Resumen de la plática Understanding the transcriptional dynamics at the single-cell level is a central challenge in deciphering developmental processes. Current sequencing technologies allow the measurement of the transcription profiles of hundreds of thousands of individual cells. However, integration of multiple single-cell transcriptomic datasets and inference of developmental progressions of cells is hampered by sampling […]