Resumen de la plática The prognosis for late-stage cancer patients is often poor, as many do not respond well to immunotherapy, targeted therapies, or their combinations. Our case studies focus on patients with mid-to-late-stage aggressive tumors who underwent histological and proteogenomic profiling to determine the most effective treatment strategies. The analysis highlights the ongoing battle […]

Resumen My lab investigates tissue-specific adaptations of dendritic cells, neutrophils and macrophages in health and non-infectious conditions with a focus on immunometabolism. I will present how mitochondria and an active electron transport chain regulate the context-dependent functions of macrophages and dendritic cells via entirely distinct molecular mechanisms. Stefanie Wculek. Head Innate Immune Biology Lab, IRB […]

Resumen de la plática: The development, implementation and improvement of genomic technologies has revolutionized the research, diagnosis and management of human diseases. From exome sequencing, and more recently whole genome sequencing, of patients with suspected genetic disorders to the large-scale sequencing of biobanks and population cohorts. However, the genomic revolution has not impacted all populations […]

Resumen The stromal microenvironment is emerging as an essential player in several chronic diseases characterized by dysregulation of immune responses, including inflammatory diseases, fibrotic diseases and cancer. Here we will discuss recent studies investigating the role of perivascular stromal niches in preventing antitumor immunity and in establishing tissue memory to allergic inflammation. Lucie Peduto, PhD. […]

Resumen de la plática Viruses and virus-like genetic elements are associated with all life on Earth. They have had major roles in the evolution of cellular life as we know it, having triggered significant biological innovations that stimulated the rise of microbial and complex life. In modern environments, viral infection is a major modulator of […]

Resumen de la plática Aging is characterized by a progressive decline in physiological function that contributes to chronic disease. Biological clocks derived from high-dimensional clinical and multi-omics data offer a promising approach for more precise tracking of aging processes and disease outcomes. Yet existing biological clocks are often limited in cross-ancestry generalizability and in their […]

Resumen: El melanoma es el tipo de cáncer de piel más peligroso. Un tipo específico de melanoma, conocido como acral (MA) es el más común en México y otros países de América Latina, África y Asia. Sin embargo, sus causas son desconocidas, y sólo se sabe que no están relacionadas con la exposición a radiación […]

Resumen Las tecnologías de célula única (scRNA-seq, ATAC-seq, proteómica y genómica espacial) han transformado nuestra capacidad de resolver la heterogeneidad celular que los métodos "bulk" tradicionalmente promediaban y ocultaban. Esta plática ofrece un panorama de las oportunidades y retos de este cambio de resolución. Entre las oportunidades, se discuten la identificación de subpoblaciones celulares raras, […]

Resumen de la plática Los sistemas fisiológicos sanos son a la vez plásticos y robustos. Es decir, responden dinámicamente a los cambios en el entorno sin desviaciones importantes ni prolongadas respecto a un punto de equilibrio homeostático. Este delicado equilibrio se logra mediante redes exquisitamente conectadas de interacciones reguladoras entre elementos biológicos como moléculas, células […]

Resumen El desarrollo de las tecnologías ómicas y del aprendizaje automático ha ampliado extraordinariamente nuestra capacidad para identificar patrones, construir biomarcadores y predecir desenlaces complejos. Sin embargo, una buena predicción no responde necesariamente las preguntas que surgen cuando queremos intervenir: ¿qué ocurriría si modificáramos una exposición, un tratamiento o un mecanismo biológico?, ¿el efecto sería […]