Teresa Tusié Luna. Instituto de Investigaciones Biomédicas UNAM, MX https://www.biomedicas.unam.mx/personal-academico/maria-teresa-tusie-luna/ Frontiers in Genomics

Resumen de la plática La población mestiza-mexicana representa una población con mezcla reciente de dos principales ancestrías: Europea y Nativo-Americana, con proporciones similares (~48% cada una). Mientras que la mayor parte de los estudios en genómica humana se han llevado a cabo en poblaciones Europeas, Asiáticas y Africanas, las poblaciones con ancestría nativa-americana están todavía […]

Resumen de la plática The prognosis for late-stage cancer patients is often poor, as many do not respond well to immunotherapy, targeted therapies, or their combinations. Our case studies focus on patients with mid-to-late-stage aggressive tumors who underwent histological and proteogenomic profiling to determine the most effective treatment strategies. The analysis highlights the ongoing battle […]

Resumen My lab investigates tissue-specific adaptations of dendritic cells, neutrophils and macrophages in health and non-infectious conditions with a focus on immunometabolism. I will present how mitochondria and an active electron transport chain regulate the context-dependent functions of macrophages and dendritic cells via entirely distinct molecular mechanisms. Stefanie Wculek. Head Innate Immune Biology Lab, IRB […]

Resumen de la plática: The development, implementation and improvement of genomic technologies has revolutionized the research, diagnosis and management of human diseases. From exome sequencing, and more recently whole genome sequencing, of patients with suspected genetic disorders to the large-scale sequencing of biobanks and population cohorts. However, the genomic revolution has not impacted all populations […]

Resumen The stromal microenvironment is emerging as an essential player in several chronic diseases characterized by dysregulation of immune responses, including inflammatory diseases, fibrotic diseases and cancer. Here we will discuss recent studies investigating the role of perivascular stromal niches in preventing antitumor immunity and in establishing tissue memory to allergic inflammation. Lucie Peduto, PhD. […]

Resumen de la plática Viruses and virus-like genetic elements are associated with all life on Earth. They have had major roles in the evolution of cellular life as we know it, having triggered significant biological innovations that stimulated the rise of microbial and complex life. In modern environments, viral infection is a major modulator of […]

Resumen de la plática Aging is characterized by a progressive decline in physiological function that contributes to chronic disease. Biological clocks derived from high-dimensional clinical and multi-omics data offer a promising approach for more precise tracking of aging processes and disease outcomes. Yet existing biological clocks are often limited in cross-ancestry generalizability and in their […]