Resumen Rhythms in energy availability, driven by earth’s 24-hour rotation, are the oldest, most consistent external input for life on earth. All life forms (from bacteria to all of our cells) have thus evolved autonomous “circadian” clocks that align physiology—from nutrient transport and uptake to breakdown and storage—to daily feeding-fasting. Chronic misalignment between endogenous and […]

Resumen Mi laboratorio se enfoca en el examen exhaustivo de la respuesta inmune contra infecciones virales, adoptando un enfoque holístico. Realizamos investigaciones tanto en células inmunes innatas como adaptativas, y más recientemente ampliamos nuestras investigaciones para comprender la intrincada interacción entre el sistema inmune y sistemas no inmunitarios. Nuestro enfoque de investigación no solo contribuye […]

Resumen Heritable traits have traditionally been attributed to mutations in germline DNA. However, emerging research reveals the pivotal role of epigenetic mechanisms, including DNA methylation, histone modifications, and small RNAs in transmitting non-genetic information across generations. In our laboratory, we explore the role of small RNAs in epigenetic inheritance using the model organism Caenorhabditis elegans. […]