Arturo Alvarez-Buylla. UCSF US https://profiles.ucsf.edu/arturo.alvarez-buylla https://youtu.be/GaWt-jANslw Frontiers in Genomics
Resumen In plants as in animals, the zygote is formed by the union of the egg and sperm. In animals, there is broad agreement that maternal transcripts and proteins inherited from the egg regulate early embryo development until the zygotic genome becomes transcriptionally active, a process termed the maternal to zygotic transition. In animals, this […]
Resumen Plants sense the hormone abscisic acid (ABA) using chemical-induced dimerization (CID) modules, including the receptor PYR1 and HAB1, a protein phosphatase inhibited by ligand-activated PYR1. This system is unique because of the relative ease with which ligand recognition can be reprogrammed. To expand the PYR1 system, we designed an orthogonal response module that harbors […]
Resumen Biomedical technology innovation holds great promise for the application of stem cells in regenerative medicine. To this end, revolutionary cellular reprogramming techniques have been developed, enabling the production of induced pluripotent stem (iPS) cells and future replacement tissues for any individual. Several groups, including our lab in Leiden, have recently adapted iPS technology to […]
Resumen To thrive on this planet with a 24 h day:night cycle, we are designed to have almost every gene in our genome to rise and fall at an appropriate time in at least one organ. This dynamic pattern of gene expression and function sustains health and vitality. Now, we live in an anthropogenic world […]
Resumen Tumor development is driven by changes to the genome leading to fitness advantages underlying successive clonal expansions. As somatic changes occur across most or all cell cycles, the cancer genome carries an archeological record of its past. Over the past years, we have developed several approaches to mine that archeological record from the cancer […]
Resumen Stress-inducible biomolecular condensates such as ribonucleoprotein (RNP) granules and DNA damage sites play major roles in cellular organization and physiology. In this talk, I will discuss how the concept of biomolecular condensates has expanded our view of stress responses and has revealed important links to aging-related diseases. I will introduce quantitative bottom-up biochemistry approaches […]
Resumen Heritable traits have traditionally been attributed to mutations in germline DNA. However, emerging research reveals the pivotal role of epigenetic mechanisms, including DNA methylation, histone modifications, and small RNAs in transmitting non-genetic information across generations. In our laboratory, we explore the role of small RNAs in epigenetic inheritance using the model organism Caenorhabditis elegans. […]
Resumen Mi laboratorio se enfoca en el examen exhaustivo de la respuesta inmune contra infecciones virales, adoptando un enfoque holístico. Realizamos investigaciones tanto en células inmunes innatas como adaptativas, y más recientemente ampliamos nuestras investigaciones para comprender la intrincada interacción entre el sistema inmune y sistemas no inmunitarios. Nuestro enfoque de investigación no solo contribuye […]
Resumen Rhythms in energy availability, driven by earth’s 24-hour rotation, are the oldest, most consistent external input for life on earth. All life forms (from bacteria to all of our cells) have thus evolved autonomous “circadian” clocks that align physiology—from nutrient transport and uptake to breakdown and storage—to daily feeding-fasting. Chronic misalignment between endogenous and […]