Frontiers in Genomics: Germano Cecere
Small RNAs in Epigenetic Inheritance

Resumen
Heritable traits have traditionally been attributed to mutations in germline DNA. However, emerging research reveals the pivotal role of epigenetic mechanisms, including DNA methylation, histone modifications, and small RNAs in transmitting non-genetic information across generations. In our laboratory, we explore the role of small RNAs in epigenetic inheritance using the model organism Caenorhabditis elegans. In my talk, I will present our findings, emphasizing the remarkable ability of small RNAs to transmit traits across generations. I provide a case study of small RNAs that progressively reduce fertility in subsequent worm generations and delve into the underlying molecular mechanisms facilitating their transgenerational transmission. Moreover, I will present recent results on the intriguing phenomenon of small RNAs migrating from the soma to the germline, enabling the inheritance of environmentally acquired information and stress resilience.

Germano Cecere. Director, Mechanisms of Epigenetic Inheritance Unit. Institut Pasteur. Department of Developmental and Stem Cell Biology

https://www.cecerelab.com

Frontiers in Genomics