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DTSTART;TZID=America/Chicago:20240402T170000
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CREATED:20240119T232511Z
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UID:4931-1712077200-1712077200@www.lcg.unam.mx
SUMMARY:Frontiers in Genomics: Simon Alberti Biomolecular condensates in cellular stress responses and disease
DESCRIPTION:Resumen\nStress-inducible biomolecular condensates such as ribonucleoprotein (RNP) granules and DNA damage sites play major roles in cellular organization and physiology. In this talk\, I will discuss how the concept of biomolecular condensates has expanded our view of stress responses and has revealed important links to aging-related diseases. I will introduce quantitative bottom-up biochemistry approaches that now allow us to reconstruct multicomponent\, active condensates such as RNP granules and DNA damage sites in the test tube. Using these approaches as well as innovative imaging and biophysics\, we have gained important insights into the molecular rules underlying condensate assembly\, such as the molecular driving forces that govern condensation\, the conformational changes underlying assembly and the molecular mechanisms of condensate regulation. I will further discuss how the concept of biomolecular condensates has allowed us to dissect the functions of stress inducible condensates\, and I will demonstrate how condensates can be used to sense and respond to changes in the environment and regulate fundamental cellular processes such as protein synthesis and DNA damage repair. \nSimon Alberti. Professor of Cellular Biochemistry. Technische Universität Dresden. Center for Molecular and Cellular Bioengineering (CMCB). Biotechnology Center (BIOTEC) \nhttp://www.biotec.tu-dresden.de/research/alberti.html \n \nFrontiers in Genomics
URL:https://www.lcg.unam.mx/event/frontiers-in-genomics-simon-alberti/
LOCATION:Auditorio “Dr. Francisco Bolivar” del IBt\, Instituto de Biotecnología UNAM Morelos\, Cuernavaca\, Morelos\, Mexico
CATEGORIES:2024-2,Frontiers in Genomics
ATTACH;FMTTYPE=image/jpeg:https://www.lcg.unam.mx/wp-content/uploads/2024/01/07-simon-alberti-168x.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20240423T170000
DTEND;TZID=America/Chicago:20240423T170000
DTSTAMP:20260430T120633
CREATED:20240119T232901Z
LAST-MODIFIED:20240417T201850Z
UID:4935-1713891600-1713891600@www.lcg.unam.mx
SUMMARY:Frontiers in Genomics:  Germano Cecere Small RNAs in Epigenetic Inheritance
DESCRIPTION:Resumen\nHeritable traits have traditionally been attributed to mutations in germline DNA. However\, emerging research reveals the pivotal role of epigenetic mechanisms\, including DNA methylation\, histone modifications\, and small RNAs in transmitting non-genetic information across generations. In our laboratory\, we explore the role of small RNAs in epigenetic inheritance using the model organism Caenorhabditis elegans. In my talk\, I will present our findings\, emphasizing the remarkable ability of small RNAs to transmit traits across generations. I provide a case study of small RNAs that progressively reduce fertility in subsequent worm generations and delve into the underlying molecular mechanisms facilitating their transgenerational transmission. Moreover\, I will present recent results on the intriguing phenomenon of small RNAs migrating from the soma to the germline\, enabling the inheritance of environmentally acquired information and stress resilience.  \nGermano Cecere. Director\, Mechanisms of Epigenetic Inheritance Unit. Institut Pasteur. Department of Developmental and Stem Cell Biology \nhttps://www.cecerelab.com \n \nFrontiers in Genomics
URL:https://www.lcg.unam.mx/event/frontiers-in-genomics-germano-cecere/
LOCATION:Auditorio “Dr. Guillermo Soberón” del CCG\, Centro de Ciencias Genómicas UNAM Morelos\, Cuernavaca\, Morelos\, Mexico
CATEGORIES:2024-2,Frontiers in Genomics
ATTACH;FMTTYPE=image/png:https://www.lcg.unam.mx/wp-content/uploads/2024/01/09-cecere-research.pasteur.fr_germano-photo.png
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BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20240430T170000
DTEND;TZID=America/Chicago:20240430T170000
DTSTAMP:20260430T120633
CREATED:20240119T233039Z
LAST-MODIFIED:20240426T173643Z
UID:4937-1714496400-1714496400@www.lcg.unam.mx
SUMMARY:Frontiers in Genomics:  Elina Zuñiga Respuesta multi-sistémica durante una infección viral
DESCRIPTION:Resumen\nMi laboratorio se enfoca en el examen exhaustivo de la respuesta inmune contra infecciones virales\, adoptando un enfoque holístico. Realizamos investigaciones tanto en células inmunes innatas como adaptativas\, y más recientemente ampliamos nuestras investigaciones para comprender la intrincada interacción entre el sistema inmune y sistemas no inmunitarios. Nuestro enfoque de investigación no solo contribuye a la comprensión de la dinámica del sistema inmunitario\, sino que también tiene potencial para desarrollar intervenciones para una amplia variedad de enfermedades humanas explotando los mecanismos regulatorios fundamentales que descubrimos. Presentaré nuestro trabajo reciente que explora la interacción recíproca entre las células T CD8 y los sistemas no inmunitarios (cerebro\, tejido adiposo) durante una infección viral. \nElina Zuñiga. Department of Molecular Biology. School of Biological Sciences. UCSD \nhttps://labs.biology.ucsd.edu/zuniga/index.htm \nhttps://biology.ucsd.edu/research/faculty/eizuniga \nhttps://youtube.com/live/5xAF9XzcY74?feature=share \nFrontiers in Genomics
URL:https://www.lcg.unam.mx/event/frontiers-in-genomics-elina-zuniga/
LOCATION:Auditorio “Dr. Francisco Bolivar” del IBt\, Instituto de Biotecnología UNAM Morelos\, Cuernavaca\, Morelos\, Mexico
CATEGORIES:2024-2,Frontiers in Genomics
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